Ongoing Clinical Projects 2012-2013

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology


Cornea
  • To compare Spectral Domain Optical Coherence Tomography (SDOCT) and Pentacam to assess corneal scars
  • Impact of aberrations post Descemet?s stripping endothelial keratoplasty on visual outcome comparing methods of specimen collection in deep keratitis cases
  • Parasitic ulcer treatment trial
  • Mycotic ulcer treatment trial
  • Acanthamoeba Keratitis longitudinal study
Glaucoma
  • Study of factors affecting adherence to glaucoma treatment protocol
  • Effect of VEGF levels in Tenon tissue on the outcome of glaucoma surgery
  • Evaluation of cell adhesion properties of Aurolab Artificial Drainage Implant in comparison with Baerveldt Implant.
  • A 3-month, open-label, non-comparative, observational study of Bimatoprost 0.01% (Lumigan?0.01%) in the clinical setting
  • Indian Family Angle Closure Evaluation (IFACE) study? Part II
  • A phase 2b double-masked, randomized, active-controlled, dose-response study assessing the safety and ocular hypotensive efficacy of AR-12286 in patients with elevated intraocular pressure for 3 months
  • A phase 2b, double-masked, randomized, active-controlled, study assessing the safety and ocular hypotensive efficacy of AR-12286 in patients with low tension glaucoma
  • A prospective evaluation of open-angle glaucoma subjects randomized to treatment with two trabecular micro-bypass stents in conjunction with cataract surgery or cataract surgery only
  • Luminous: Study to observe the effectiveness and safety of Lucentis through individualized patient treatment and associated outcomes
  • Survey: Glaucoma Awareness in Patients
  • Evaluation of postgraduate clinical education in a tertiary eye care system
  • Cost effectiveness analysis of anti glaucoma medications
  • Genetic analysis of MFRP (Membrane Frizzled Related Protein) and evaluation of phacoemulsification with or without anterior sclerostomy in nanophthalmic eyes
  • A prospective, randomized, controlled clinical trial comparing topical medical therapy with Selective Laser Trabeculoplasty (SLT) as initial treatment for open angle glaucoma in south Indian population
  • Merck - Compare the efficacy and safety of preservative free MK - 2452 (0.0015%) and preservative free Timolate Maleate (0.5%) in patients with POAG and OHT
  • Research study: Genetic screening in a large family with primary open angle glaucoma
Cataract
  • Comparison of refraction stabilization and surgical induced astigmatism between microincision phacoemulsification surgeries
  • Aravind Pseudoexfoliation IOL study- genetic Analysis
  • Comparison of the reduction in IOP, changes in corneal endothelial cell count and anterior chamber angle parameters using ASOCT following clear corneal phacoemulsification with manual small incision cataract surgery
  • To study the safety and efficacy of topical Nepafenac eye drops with topical Prednisolone acetate in patients undergoing YAG peripheral iridotomy
  • Barriers to acceptance of cataract surgery
  • The role of homocysteine in Aravind Pseudoexfoliation IOL Study
  • Clinical evaluation of Toric intraocular lens made by Aurolab
  • The natural history of intraocular lens in eyes with exfoliation syndrome (APEX IOL Study); multicentric
  • Counseling for Cataract Surgery: Effect on patient knowledge, decisional conflict and satisfaction
  • Prospective Review of Early Cataract Outcomes and Grading (PRECOG)
  • A prospective open label observational study to evaluate the safety and surgical performance of surgical blade (Aurosleek) in cataract patients.
  • Comparison of complication rates between Phaco and MSICS at Aravind Eye Hospital
Retina
  • Non randomized control study of comparing 20% Sulphurhexafluride [SF6] with 100% Sulphurhexafluride [SF6] in macular hole surgery
  • Non randomized control study of comparing Sclera Fixated Intraocular Lens [SFIOL] implantation vs Iris Fixated Intraocular Lens [IFIOL] implantation in cases with inadequate posterior capsular support
  • A pilot study comparing the portable retina camera (CavCam XII) to the Topcon Retina Camera
  • AMD phenotype study
  • Visual outcome and optical coherence tomographic features in patients undergoing vitrectomy for Rhegmatogenous retinal detachment
  • Autofluorescence imaging, spectral-domain optical coherence tomography, HFA and visual function correlation in patients with retinitis pigmentosa
  • Study to observe the effectiveness and safety through individualized patient treatment and associated outcomes
  • A 12 month, open label, multicenter study to evaluate the efficacy and safety of intravitreal injections of ranibizumab 0.5mg on cystoids, Spongy and Mixed patterns secondary to Diabetic Macular Edema
  • Genetic analysis of NR2E3 gene in a family with enhanced S cone syndrome and vasoproliferativetumour of retina
  • Study to evaluate utility of DNA macrochip in clinical management and outcomes in endophthalmitis
  • A randomized control study of ILM Peeling with Indocyanine Green, Tryphan Blue and Brilliant Blue dyes used in macular hole surgery
Uvea
  • A phase III, multinational, multicentre, randomized, double-masked, study assessing the safety and efficacy of intravitreal injections of DE-109 (three doses) for the treatment of active, non-infectious uveitis of the posterior segment of the eye.
  • Etiology and immunopathogenesis of subconjunctival and anterior chamber granulomatous uveitis in children
Pediatric
  • Sensitivity and specificity of teachers screening during school screening programme
  • Academic performance of school children-before and after wearing spectacles
  • Training all the class teachers Vs conventional training method- a comparative study
  • Barrier for referrals under 0 - 5 years age group
  • Compliance on wearing spectacles
  • Surgical outcome of large V pattern
Orbit
  • National retinoblastoma registry - ICMR
  • Translational Research to Generate Corneal/Buccal Epithelial Stem Cells with GMP Compliance for Corneal Surface and Socket Reconstruction
  • Identification of mitochondrial biomarkers in retinoblastoma
  • Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets
  • An open label, prospective clinical evaluation of safety and efficacy study of Aurostent (Silicone mono canalicular lacrimal stent manufactured by Aurolab, Madurai, India) in the treatment of canalicular injuries and anomalies
  • Establishing the genetic testing centre for childhood ocular cancer (retinoblastoma) in Aravind Medical Research Foundation
Low vision
  • Effectiveness of low vision referrals: An assessment of patient quality of life and physician perceptions of low vision services at Aravind Eye Hospital
Neuro-ophthalmology
  • Factors affecting the course and outcome of ischemic oculomotor, trochlear and abducens nerve palsy

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