OCULAR PHARMACOLOGY


The main research focus of the department is to understand the pathogenic mechanism and to identify drug targets for age-related ocular diseases such as diabetic retinopathy (DR), Age-related Macular Degeneration (AMD), Glaucoma and cataract.

Research areas

  Role of Aldose Reductase in Retinal pigment epithelium an understanding towards the pathogenesis of diabetic retinopathy
  Evaluating the Role of Macular Carotenoids in the Accumulation of A2E, a Fluorophore in the Pathogenesis of Age-related Macular Degeneration
  Human Organ Culture Anterior Segment (HOCAS) for Trabecular Meshwork Studies

Ongoing Projects

  • Role of Aldose Reductase in Retinal Pigment Epithelium - An Understanding Towards the Pathogenesis of Diabetic Retinopathy. Funding Agency: DBT - RGYI (2011-2013).
  • Evaluating the Role of Macular Carotenoids in the accumulation of A2E, a fluorophore in the pathogenesis of Age-related Macular Degeneration. Funding Agency: DST - Fast Track (2012-15).
  • Indian Macular Carotenoid Research (IND-MACARE) - A Feasibility study. Funding Agency: ICMR

Completed projects

  • Evaluation of a suitable in vitro model for diabetic retinopathy. Funding Agency: Champalimaud Research Grant (2009 - 2010).
  • Topical Kinetics of voriconazole (1% & 0.1% w/v) in human. Funding Agency: Champalimaud Research Grant (2009-2010)
  • To find out the association of Vitamin "A" deficiency and the severity of Vernal Kerato Conjunctivitis. Funding Agency: Champalimaud Research Grant (2010-2011)
  • Exploratory Study on Ascorbate (Vitamin C), Haptoglobin in Cataract Patients. Funding Agency: AMRF (2010-2011).
  • Screening of human donor optic discs for the history of glaucoma. Funding Agency: AMRF (2010-2011).
  • Human Organ Culture Anterior Segment Studies on Trabecular Outflow. Funding Agency: Aravind Eye Foundation, (2011-2012).
  • A Pilot Study to understand the relationship between vitreous and plasma ascorbate in patients undergoing vitrectomy surgery. Funding Agency: AMRF (2011-2012).

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