PROTEOMICS

Current research focus is on three specific areas namely fungal keratitis, diabetic retinopathy and primary open angle glaucoma. Fungal keratitis is a disease, most common in developing countries like India, Bangladesh, Nepal and China; hence knowledge gained will immensely benefit people from the lower socio economic group. The sheer importance of diabetic retinopathy and the lack of effective screening mechanisms for primary open angle glaucoma have prompted us to concentrate on these two common eye diseases. The aim of the research carried out is to apply a variety of proteomic tools to understanding the host pathogen mechanisms and to identify new diagnostic, prognostic and therapeutic biomarkers for these diseases. Recently substantial grant was given by DBT-Govt. of India, as a programme that support to study human mycotic keratitis and the causative fungi and bacteria. The mechanism of the pathogenesis would be studied using proteomics using both the host and the pathogen in the coming years.

Research Areas

Fungal Keratitis
Host-Pathogen interaction
Diabetic Retinopathy
Primary Open Angle Glaucoma

Ongoing Projects

CoE - Programme support on Human Mycotic Keratitis, Funding Agency: Department of Biotechnology, Govt. of India

Core Project: Functional genomics and proteomics of fungal pathogenome and host immune response to fungal infection in human mycotic keratitis
Project 1: Quantitative proteomics and analysis of disease specific post translational modifications of tear, cornea and sera of keratitis patients
Project 2: Biology of human ocular fungal pathogens: comparative proteomics of virulent and avirulent Aspergillus and Fusarium.
Project 3: Functional genomics of a fungal pathogen Aspergillus fumigatus.

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