Bioinformatics

The Bioinformatics Department has been established at Aravind Medical Research Foundation (AMRF) in 2012 to carry out research in bioinformatics and computational biology and to aid translational vision research. Bioinformatics is an emerging field between biological and computational sciences, which has become essential part in vision research today. The necessity of Bioinformatics in medical research is to understand the biological processes at the molecular level.
      The department primarily focuses on developing bioinformatics methods of omics analysis and noncoding RNAs for eye diseases. Current research foci are i) whole genome, exome, transcriptome next-generation sequencing data analysis in identifying molecular targets for ocular cancer and diseases, ii) network approaches and multi-omics data integration to identify microRNAs and their regulatory role in eye diseases, iii) comparative genome analysis to identify genomic variants and genes associated with drug resistance in ocular pathogens such as Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa and iv) structure and sequence based approaches of non-synonymous variants (nsSNVs) to understand the molecular mechanisms for pathogenicity.
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Research Areas

  • MicroRNAs and their regulatory role in the vision and eye diseases
  • Comparative genomics for bacterial drug-resistance mechanisms and evolution
  • whole genome, exome, transcriptome next-generation sequencing data analysis in identifying molecular targets for eye cancer and other eye diseases
  • Structural bioinformatics of non-synonymous variants (nsSNVs)

On-going Projects

  1. Clinical exome analysis pipeline for eye disease next-generation sequencing panel
  2. Regulatory role of human MicroRNAs in Microbial Keratitis
  3. Comparative genome analysis to identify genomic variants and genes associated with drug resistance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa ocular strains
  4. Functional analysis of circulating miRNAs and their regulatory role in Diabetic retinopathy
  5. Limbal miRNAs and their potential targets associated with the maintenance of stemness

Bioinformatics and NGS data analysis services:

  1. Exome data analysis
  2. Targeted/Amplicon sequence data mutation analysis
  3. De novo bacterial assembly and genome comparison
  4. RNA-seq data analysis
  5. Small-RNA seq data analysis

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