Ongoing Clinical Projects 2021-2022

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology
Cornea clinic
  • Changes in endothelial specular microscopy findings: A comparison before and after hypotonic corneal collagen cross- linking
  • To compare femtosecond laser assisted LASIK (femto-LASIK) and photorefractive Keratectomy (PRK) in terms of astigmatism correction in patients with myopic cylindrical error
  • Screening, diagnosis, and treatment of keratoconus in Downs’s syndrome patients from South India- a prospective study
  • Effect of COVID-19 on outcome of corneal ulcers – A retrospective multicentre study in tertiary eye hospitals of South India
  • Outcomes of early steroids and corneal collagen crosslinking (cxl) adjuvant therapy in bacterial keratitis – A randomized control trial
  • PCR-based detection and identification of and its species from patients with keratitis
  • Knowledge, attitude and practice towards eye donation among ambulance workers and freezer box service providers – A questionnaire based study
  • Strategies to improve outcomes following corneal transplant surgery: An interprofessional approach. Trends in transplantation
  • Artificial intelligence applications in different imaging modalities for corneal topography.
Paediatric ophthalmology and Adult Strabismus Clinic
  • Assessment of parental awareness about paediatric visual problems by a knowledge-attitude-practice (KAP) survey
  • Correlation of refractive error in siblings of paediatric patients attending a tertiary level eye hospital
  • Identification of potential barriers to timely access to sibling eye check up
  • Effect of combined atropine and patching Vs patching alone for treatment of severe amblyopia in children aged 3 to 12 Years
  • Multi-centric randomised controlled trial to compare the efficacy of 0.01 vs 0.05% atropine in progression of myopia in Indian population
  • A step further in childhood cataract: Screening, evaluation, management, rehabilitation and training- Focus to eliminate childhood blindness due to cataract in south India
  • To detect macular vessel density changes after inferior oblique muscle recession surgery
  • Steroids and cross-linking for ulcer treatment
  • Parasitic ulcer pilot study
  • Automated quantitative ulcer analysis study
  • Metagenomic analysis and diagnosis of ulcers rapidly with artificial intelligence hCes II screening study
  • Rose Bengal electromagnetic activation with green light for infection reduction study Scope II (ocular trauma)
  • Seasonal conjunctivitis outbreak reporting for prevention and improved outcomes
  • A multicentre randomised controlled trial to compare the efficacy of 0.01 Vs 0.05% Atropine in progression of myopia in Indian population.
  • Effect of video counselling versus pamphlets on awareness of refractive error among parents of children with newly diagnosed refractive error
  • Augmented loop Myopexy with IOL in heavy eye syndrome
  • Retrospective case series on eye movement recordings in periodic alternating nystagmus
  • Role of LDA in myopic progression in Indian population
  • Validation of Go-check kid based photo screener as hand-held tool for detecting amblyopia risk factors in Indian population
  • Filamentary keratitis post strabismus
  • Role of VEP and Bynocs -pre and post squint surgery in amblyopia patients
  • Acute onset esotropia post lockdown
  • Optic nerve glioma in children
  • Retrospective analysis of surgical outcome of Brown’s syndrome
  • Electrophysiological changes in patients with Bardet Biedl syndrome
  • Motility assessment in glaucoma drainage devices
  • Retrospective study on the profile of secondary IUr in paediatric patients
  • Infantile esotropia – Retrospective study
  • Comparison of measurement of abnormal head posture by smartphone application vs cervical range of motion (CROM) in ophthalmic disorders
  • Validation of GoCheck Kids iPhone-based photoscreener as a hand-held tool for detecting amblyopia risk factors in an Indian paediatric population
  • A multi-center randomised controlled trial to compare the efficacy of 0.01 vs 0.05% atropine in progression of myopia in Indian population.
  • Prospective evaluation of motility in glaucoma drainage device implantations
Glaucoma clinic
  • Comparative analysis of non-absorbable 10-0 nylon sutures with absorbable 10-0 Vicryl sutures in Phaco-trabeculectomy surgery
  • Comparison of viscoat augmented delivery of injection mitomycin-C and conventional subconjunctival injection of Mitomycin C in Phacotrabeculectomy
  • To compare the anxiety levels of glaucoma patients undergoing visual field testing and UCs
  • Randomised control trial: Once daily netarsudil versus twice daily Timolol in patients with elevated intraocular pressure
  • Post-operative outcomes of phacotrabeculectomy and small incision cataract surgery with intraocular lens implantation with mitomycin C in patient with advanced glaucoma with split
  • fitations in humphrey isual field
  • Surgical outcome of Tanito microhook ab Interno trabeculotomy with phacoemulsification orotb Gs Conioscopy-Assisted Transluminal Trabeculotomy (GATTb with phacoemulsification in
  • patients with mild to moderate open angle glaucoma – A randomized comparative study at a tertiary eye care centre
  • so assess the safety D efficacy of combined phacoemulsification- trabeculectomy versus phacoemulsification – non-penetrating deep sclerostomy (NPDS) in advanced glaucoma. – A
  • randomised control study at A tertiary care centre
  • Enhancing early glaucoma detection through family screening to reduce glaucoma related blindness
  • Shared medical appointments randomised trial
  • The Asia primary tube versus trab (TVT) study
  • Comparison of new head mount perimeteri C( isual field analy)er GI with standard -umphreyRs field analyser
  • Evaluation of the accuracy of an automated algorithm for glaucoma detection from colour fundus photographs taken on a low-cost, slit lamp based Remidio fundus-on-phone camera and a
  • high-tech Topcon camera as compared to the gold standard clinical evaluation
  • Safety and stability of topical anti-glaucoma medications: a randomised prospective observational study
  • Non-inferiority of nano dropper-mediated microdrops vs standard drops of 0.5% Timolol Maleate in patients with open- angle glaucoma or ocular hypertension
  • An open label, multicentre, phase iii, prospective study to evaluate the efficacyi safety and tolerability of triple fited dose combination of Timolol 0.5% + Brimonidine 0.2% + Brinzolamide 1%
  • eye drops in patients with open angle glaucoma/ocular hypertension not responding to dual drug therapy
  • A randomised, multicentre, active controlled, parallel-group study to assess efficacy and safety of fited dose combination of Netarsudil and Latanoprost ophthalmic solution (0.02% w/v +
  • 0.005% w/v) in comparison with Latanoprost Eye Drops 0.005% w/v) in patients with open angle glaucoma or ocular hypertension
  • A comparison of the efficacy and cardio ascular ad erse e ents between conventional, commercial 0.5% timolol maleate and 10 μL drops of 0.5% timolol maleate using a Nanodropper adaptor
  • in adults with primary open-angle glaucoma or ocular hypertension
  • Comparison of transpalpebral Easyton tonometer with Goldman applanation tonometer in persons with glaucoma
  • Improving adherence to follow-up in childhood glaucoma
  • Family screening of glaucoma
  • Risk of progression in incident versus prevalent gonioscopic angle closure
Retina and vitreous clinic
  • Efficacy and impact of artificial intelligence based retinal screening at rural primary eye care centers in southern India
  • A prospective study to evaluate the early real-world evidence of Brolucizumab in patients with Polypoidal Choroidal Vasculopathy (PCV)
  • Evaluation of bioclinical markers as predictors of non-responders to intravitreal antiVEGF in diabetic macular edema
  • A randomised, active-controlled, double-masked, parallel- groupi phase ( study to compare efficacy and safety of ct-p42 in comparison with Eylea in patients with diabetic macular edema
  • A 96 week, two-arm, randomised, single-masked, multicentre, phase III study assessing the efficacy and safety of brolucizumab 6mg compared to panretinal photocoagulation laser in
  • patients with proliferative diabetic retinopathy
  • A phase 3, comparative, double-blind, randomised, multicentre study to compare the efficacy safety and immunogenicity of hunRs Ranibizumab with reference biologic in patients with
  • neovascular age-related macular degeneration
  • A phase 3, randomised, double-blind, parallel group, multicentre study to compare efficacy safety pharmacokinetics and immunogenicity of BP05 versus EU-Approved Lucentis® in
  • patients with wet (neovascular) age-related macular degeneration
  • Subjective high-risk patient counselling randomisation project
  • A study on the differential expression of Piwi-interacting RNAs (piRNA) and altered Piwi-like protein interactions in diabetic retinopathy
  • Comparison of staging of diabetic retinopathy by an offline artificial intelligence with onsite doctor etamination and fundus grading by retina specialist
  • Improving retinopathy of prematurity telemedicine systems in south India
  • Genetic characterization of macular telangiectasia in the Indian Population
  • A double masked, parallel group, randomized, multicentre, clinical study to compare efficacy and safety of Intas Ranibizumab with Lucentis® in patients with neovascular (wet) age-related
  • macular degeneration
  • Comparative study of Aurolab’s multispot green laser with already available green Laser (PASCAL) in proliferative diabetic retinopathy patients.
  • Accuracy of smart phone based mydriatic fundus camera in the detection of CMV retinitis
  • Efficacy of Bevacizumab with panretinal photocoagulation versus panretinal photocoagulation alone in proliferative diabetic retinopathy: a sham-controlled trial
  • To evaluate patient compliance for prone positioning after vitrectomy surgery using an innovative device
  • Improving RoP telemedicine systems in south india
  • An extension study to evaluate the long term efficacy and safety of Ranibizumab compared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity
  • Statistical modelling and risk assessment of Type 2 diabetes complications in India
  • EYLEA Study: Structured post-marketing surveillance to collect the safety data of intravitreal aflibercept injection (IVG-AFL) in patients of wet age-related macular degeneration during real
  • world clinical practice.
  • Scope: ROP Tele screening study
  • FOCUS Study: Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes
  • INSIGHT Study: A multi centre, randomised, double-masked, active-controlled, comparative clinical study to evaluate the efficacy and safety of M5r-%F0%P and Eylea® in subjects with
  • diabetic macular edema
  • VISIBLE Study: A randomised, phase 3, double-masked, parallel group multicentre study to compare efficacy and safety of QL1205 versus lucentis in subjects with Neovascular ARMD
  • INSIGHT Extn Study: A multicentre, extension study to evaluate the safety and efficacy of M5r-%F0%P in subjects with diabetic macular edema completed M5r-%F0%P-(00% study
Neuro-ophthalmology clinic
  • A pharmacogenomics study to identify genetic risk factors for development of ethambutol optic neuropathy
  • Evaluation of Ethambutol induced optic neuropathy in adults with tuberculosis
Cataract and IOL clinic
  • Natural history of IOL in eyes with exfoliation syndrome
  • Visual performance comparison between phacoemulsification and manual small incision cataract surgery in eyes with senile cataract: a prospective randomized clinical trial
  • Comparative analysis of single dose perioperative sub- conjunctival depotsteroid to routine topical steroids in uncomplicated phacoemulsification
  • A comparative analysis of simulator based training and traditional wetlab training on the cataract surgical outcome in manual small incision cataract surgery: A prospective study
  • Validation of cataract detection tool: an artificial intelligence based App on android mobile
  • Effect of Nd: YAG laser posterior capsulotomy on higher order aberrations
  • Characterization of adult human lens epithelial stem cells in the maintenance of tissue homeostasis throughout life and their functional status in cataractous lens
  • To study the safety and performance of high refractive index cast molded hydrophobic IOLs with age-related cataract patients
  • Effect of preloaded capsular tension ring (CTR) on clinical outcomes during and after phacoemulsification cataract surgery
  • A prospective, randomized, double blind, comparative study to evaluate the surgical performance of Nanocut and Aurolab’s round stock surgical blades for making corneal incisions during
  • cataract surgery
  • ES 900 penetration in dense cataract
  • Evaluation of cataract refractive outcomes in eyes with a history of laser vision correction using Zeiss IUrmaster F00 with total keratometry
  • Complaints and ocular manifestation in post Covid patients (second wave) presenting at tertiary eye hospitals
  • Reasons for delay in patients with advanced cataracts during the COVID-19 pandemic
  • Comparative analysis of single dose intraoperative sub- conjunctival depot steroid to routine topical steroids and NSAIDs in phacoemulsification
  • Evaluation of the Nallasamy formula: A machine learning method for refraction prediction in cataract surgery in Indian eyes
Uvea
  • A phase III, multicentre, sham-controlled, randomised, double- masked study assessing the efficacy and safety of intravitreal injections of 440 µg DE-%0I for the treatment of active, non-infectious uveitis of the posterior segment of the eye