Ongoing Clinical Projects 2022-2023

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology
Glaucoma clinic
  • Screening the Kadaladi family with early onset glaucoma for Myocilin gene mutations and development of ER stress reversing novel chemical entities as topical ophthalmic formulations
  • A prospective, randomised, comparative study of efficacy and safety of subtenon injectable 20μg Mmc Vs 40μg Mmc in trabeculectomy patients
  • A comparative analysis of non-absorbable 10-0 nylon sutures with absorbable 10-0 Vicryl sutures in phaco-trabeculectomy surgery
  • A comparison of viscoat augmented delivery of injection mitomycin-C and conventional subconjunctival injection of Mitomycin C in phacotrabeculectomy
  • Randomised control trial: Once daily Netarsudil Vs twice daily Timolol in patients with elevated intraocular pressure
  • Surgical outcome of Tanito microhook ab interno trabeculotomy with phacoemulsification Vs gonioscopy-assisted transluminal trabeculotomy with phacoemulsification in patients with mild to moderate open angle glaucoma: A randomised comparative study at a tertiary eye care centre
  • To assess the safety and efficacy of combined phacoemulsification trabeculectomy Vs phacoemulsification- non penetrating deep sclerostomy in advanced glaucoma – A randomised control study at a tertiary care centre
  • To evaluate the efficacy and safety of Aurolab aqueous drainage implant on intraocular pressure reduction in paediatric patients with refractory glaucoma
  • Asia primary tube versus trab study
  • Shared medical appointments randomised trial
  • Enhancing early glaucoma detection through family screening to reduce glaucoma related blindness
  • Screening of juvenile open angle glaucoma patients and their family members for myocilin gene mutations
  • Evaluation of the accuracy of an automated algorithm for glaucoma detection from colour fundus photographs taken on a low-cost camera as compared with the gold standard clinical evaluation – A prospective study
  • Safety and stability of topical Latanoprost eye drops: A randomised prospective observational study
  • Non-inferiority of Nanodropper-mediated microdrops vs. standard drops of 0.5% timolol maleate in patients with open-angle glaucoma or ocular hypertension
  • Smart phone drop reminder app and smart box
  • Family – primary glaucoma evaluation study
  • Improving adherence to follow-up in childhood glaucoma
  • Family screening of glaucoma
  • An open label, multicentric, phase III, prospective study to evaluate the efficacy, safety and tolerability of triple fixed dose combination of Timolol 0.5% + Brimonidine 0.2% + Brinzolamide 1% eye drops in patients with open angle glaucoma/ocular hypertension not responding to dual drug therapy
  • A randomised, multicentric, active controlled, parallel-group study to access efficacy and safety of fixed dose combination of Netarsudil and Latanoprost ophthalmic solution (0.02%w/v + 0.005% w/v) in comparison with Latanoprost eye drops (0.005% w/v) in patients with open angle glaucoma or ocular hypertension
  • A comparison of the efficacy and cardiovascular adverse events between conventional, commercial 0.5% Timolol maleate and 10 μL drops of 0.5% Timolol maleate using a nanodropper adaptor in adults with primary open-angle glaucoma or ocular hypertension
  • Comparing outcomes of femto laser assisted cataract surgery to conventional phacoemulsification in nanophthalmos eyes – A randomised controlled trial
  • Structural and functional correlation in nanophthalmic eyes
  • Factors affecting follow-up adherence of glaucoma patients
  • An analysis of re-surgeries following primary glaucoma surgical interventions
  • Long term surgical outcomes of glaucoma associated with Sturge Weber syndrome in Children
  • Factors affecting diabetic retinopathy patients’ adherence to scheduled follow-up
  • Role of miRNA in the regulation of glucocorticoid receptor signalling and development of new therapeutics for steroid-induced glaucoma
  • Real world data collection of VISULAS green selective laser trabeculoplasty in routine office / hospital use
Cataract clinic
  • To compare the effect of existing hydrophilic intraocular lens and newly designed hydrophilic intraocular lens over posterior capsule opacification rates in cataract patients
  • To assess the safety and efficacy of posterior chamber phakic intraocular lens in patients with high myopia
  • Comparative analysis of single dose intraoperative sub- conjunctival depot steroid to routine topical steroids and NSAIDS in phacoemulsification
  • The natural history of IOL in eyes with exfoliation syndrome
  • Visual performance comparison between phacoemulsification and manual small incision cataract surgery in eyes with senile cataract: A prospective randomised clinical trial
  • Comparative analysis of simulator-based training and traditional wetlab training on the cataract surgical outcome in manual small incision cataract surgery: A prospective study
  • Validation of cataract detection tool: An artificial intelligence based app on android mobile
  • Effect of Nd: YAG laser posterior capsulotomy on higher order aberrations
  • Characterisation of adult human lens epithelial stem cells in the maintenance of tissue homeostasis throughout life and their functional status in cataractous lens
  • To study the safety and performance of high refractive index cast molded hydrophobic intra ocular lenses with age-related cataract patients
  • Effect of preloaded capsular tension ring on clinical outcomes during and after phacoemulsification cataract surgery
  • A prospective, randomised, double blind, comparative study to evaluate the surgical performance of Nanocut and Aurolab round stock surgical blades for making corneal incisions during cataract surgery.
  • Detection of posterior capsule integrity in posterior polar cataract during pre-operative biometry using IOL master 700
Cornea clinic
  • Steroids and cross-linking for ulcer treatment
  • Screening, diagnosis, and treatment of keratoconus in Down’s syndrome patients from South India- A prospective study
  • To assess the safety and efficacy of posterior chamber phakic intraocular lens in patients with high myopia
  • A prospective study of postoperative astigmatism in 1 year post penetrating keratoplasty patients in a tertiary care hospital in south India
  • PCR based detection and identification of Microsporidia (Coarse SPK) and its species from patients with keratitis
  • Standard Vs novel medication form based counselling for corneal ulcer
  • Automated quantitative ulcer analysis study
  • Rose Bengal electromagnetic activation with green light for infection reduction study
  • Seasonal conjunctivitis outbreak reporting for prevention and improved outcomes
  • Epidemiology and rapid diagnosis of fungal keratitis in India: A multicentric approach
  • Identification of druggable targets for attenuating the progression of pterygium development
  • Role of human corneal MiRNAs in the onset and severity of fungal keratitis
  • Prediction of the identity of the fungal pathogen (Fusarium vs A. flavus) using tear protein as diagnostic markers
  • Role of extracellular vesicles in the modulation of host immune response in fungal keratitis
  • Diagnostic accuracy of smartphones for photographing corneal scars
Paediatric Ophthalmology
  • A multi-centric, randomised, controlled trial to compare the efficacy of 0.01 Vs 0.05% atropine in progression of myopia in the Indian population
  • Assessment of parental awareness about paediatric visual problems by a knowledge-attitude-practice (KAP) survey
  • Correlation of refractive error in siblings of paediatric patients attending a tertiary level eye hospital
  • Identification of potential barriers to timely access to sibling eye check up
  • Effect of combined Atropine and patching Vs patching alone for treatment of severe amblyopia in children aged 3 to 12 years
  • Augmented loop Myopexy with IOL in heavy eye syndrome
  • Role of LDA in myopic progression in Indian population
  • Filamentary keratitis post strabismus
  • Other eye surgery in patients with traumatic 3rd nerve palsy
  • Unique case of isolated superior oblique Palsy
  • Acute onset esotropia post lockdown
  • Optic nerve glioma in children
  • Motility asssessment in glaucoma drainage devices
  • Profile of secondary IOL in paediatric patients: A retrospective study
  • Bynocs Vs patching combined squint +IOL in paediatric population
  • Surgical outcome of Helveston syndrome
  • Outcome of cataract surgery in children with congenital glaucoma having Aurolab aqueous drainage implant
  • Surgical outcomes of superior oblique tuck as a single surgery for acquired superior oblique palsy – A retrospective analysis
  • Adjustable strabismus surgery in children under general anaesthesia -A retrospective observational study
  • Unilateral resect recess for near distance disparity in convergence insufficiency exotropia
  • ERG in nanophthalmos
Retina clinic
  • Efficacy and impact of artificial intelligence based retinal screening at rural primary eye care centres in southern India
  • Subjective high-risk patient counselling randomisation project
  • Genetic characterisation of macular telangiectasia (MacTel) 2 in the Indian population
  • A study on the differential expression of Piwi-interacting RNAs(piRNAs) and altered Piwi-like protein interactions in diabetic retinopathy
  • A double masked, parallel group, randomised, multicentre, clinical study to compare efficacy and safety of Intas Ranibizumab with Lucentis® in patients with neovascular (wet) age-related macular degeneration
  • Clinical profile and multimodal imaging characteristics of macular telangiectasia type 2 in Indian population
  • Validation of an offline artificial intelligence system integrated on a smartphone fundus camera for age-related macular degeneration screening
  • An extension study to evaluate the long term efficacy and safety of Ranibizumab compared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity
  • Structured post-marketing surveillance to collect the safety data of intravitreal Aflibercept injection in patients with wet age-related macular degeneration during real world clinical practice
  • Improving retinopathy of prematurity telemedicine systems in south India
  • Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes
  • A phase III, comparative, double blind, randomised, multi centre study to compare the efficacy, safety and immunogenicity of Sun’s Ranibizumab with reference biologic in patients with neovascular age-related macular degeneration
  • A randomised, phase 3, double-masked, parallel group, multicentre study to compare efficacy and safety of QL1205 versus Lucentis in subjects with neovascular age-related macular degeneration
  • A multicentric, extension study to evaluate the safety and efficacy of MYL-1701P in subjects with diabetic macular edema completed MYL-1701P-3001
  • A randomised, active-controlled, double-masked, parallel-group, phase 3 study to compare efficacy and safety of CT-P42 in comparison with Eylea in patients with diabetic macular edema
  • Accuracy of smart phone based mydriatic fundus camera in the detection of CMV retinitis
  • A prospective study for ocular and systemic pathologies
  • Evaluation of topical Hydroxypropyl methylcellulose in reducing the post intravitreal injection discomfort through a questionnaire
  • A pilot study to understand the impact of Zydus Cadila’s Bevacizumab with Roche’s Bevacizumab in patients with retinal pathology
  • A comparative study to determine the impact of an altered patient flow using fundus imaging in the general OPD of a tertiary eye hospital in south India
  • A prospective study to evaluate the early real-world evidence of Brolucizumab in patients with polypoidal choroidal vasculopathy
  • Knowledge, attitude and practice (KAP) Questionnaire study on retinopathy of prematurity among ophthalmologists in a tertiary care hospital
  • Laser for retinopathy of prematurity under subtenon anesthesia – A randomised control study
  • A randomised clinical trial to determine the impact of an altered patient flow using fundus imaging in the general OPD of a tertiary eye hospital in south India
  • Anatomical outcomes of posterior sclerostomy with and without Mitomycin C in nanophthalmos with uveal effusion syndrome
  • Combined pars plana vitrectomy with inferior endolaser ablation of pars plana in neo-vascular glaucoma
  • Comparative analysis of the outcome of large macular holes operated with platelet rich plasma derived nanovesicles versus platelet rich plasma
  • Establishment of Aravind registry for inherited diseases of the eye
  • Intraocular lens type and retinal oxidative stress
  • A pilot study to assess the efficacy of oral Lamivudine for macular edema due to retinal vein occlusions
  • Deep Learning-based automated macular fluid quantification and predictive analytics for patients with BRVO
  • Intravitreal Triamcinolone acetonide for macular edema in hypertensive retinopathy
  • Clinical features, management and outcome of diabetic retinopathy complicated by chronic myeloid leukemia
  • Intravitreal Dexamethasone implant (Ozurdex) combined with vitrectomy for diabetic macular edema
  • Clinical profile, microbiological study, and follow up of scleral buckle removal – 12 years of experience from a tertiary eye centre
  • Factors affecting diabetic retinopathy patients’ adherence to scheduled follow-up
  • A prospective comparative study of Lutein and Zeaxanthin adjunctive therapy with pars plana vitrectomy in macula of rhegmatogenous retinal detachment
  • A 96-week, two-arm, randomised, single-masked, multicentre, phase III study assessing the efficacy and safety of Brolucizumab 6 mg compared to panretinal photocoagulation laser in patients with proliferative diabetic retinopathy
  • A phase 3, randomised, double-blind parallel group, multicentre study to compare efficacy, safety, pharmacokinetics, and immunogenicity of BP05 Versus EU- Approved Lucentis® in patients with wet (neovascular) age-related macular degeneration.
  • A randomised, double-masked, parallel-group, multicenter clinical study to evaluate the efficacy and safety of AVT06 Compared with EU-Eylea® in subjects with neovascular (wet) age-related macular degeneration
  • A phase III, prospective, randomised, parallel group, double-blind, multicentre study to compare the efficacy, safety, and immunogenicity of Lupin’s Aflibercept with Eylea® in patients with neovascular age-related macular degeneration
Orbit and Oculoplasty
  • The learning curve in external dacryocystorhinostomy: Experience of a fellowship trainee at a tertiary care centre
  • Translational genomics of ocular cancers
General Ophthalmology
  • Remote mobile phone app for diagnosis of anterior segment disease – a new model for community based screening
Uvea
  • Diagnostic markers for ocular tuberculosis
  • A phase III, multicentre, sham-controlled, randomised, double-masked study assessing the efficacy and safety of intravitreal injections of 440 μg DE-109 for the treatment of active, non-infectious uveitis of the posterior segment of the eye
Neuro-ophthalmology
  • Role of microperimetry in toxic neuropathy and optic neuritis- A cross sectional study
  • Demographic profile and ophthalmic manifestations of ocular myasthenia- A hospital based retrospective study
  • Neuro ophthalmic manifestations of tuberculosis
  • Neuro ophthalmic manifestations in thyroid disorder- A five year retrospective study