Ongoing Clinical Projects 2017-2018

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology
Glaucoma
  • A Clinical Validation Study for evaluating the performance of RIA-G software for automated detection of optic nerve head changes on fundus photographs/images
  • Validation of the Compressed Assessment of Ability Related to Vision (CAARV), a Performance Based Measure, in a South Indian Population with Glaucoma
  • A correlative study of pupillary response as measured by automated monocular pupillometer (Neuroptics plr™-3000) with Retinal Nerve Fiber layer thickness and visual field in varying severities of glaucoma
  • Surgical outcome of piggyback intraocular lens implantation after phacoemulsification in nanophthalmic eyes
  • Endothelial cell loss after Phacoemulsification in nanophthalmic eyes undergoing cataract surgery
  • Clinical and histopathological correlation of the sclera in nanophthalmic eyes undergoing cataract surgery
  • Robison D. Harley, MD CGRN International Pediatric Glaucoma Registry
Cataract
  • The Natural History of Artificial Intraocular Lenses in Eyes with Exfoliation Syndrome (APEX IOL Study)
  • Prostaglandin level estimation in phacoemulsification and Femtosecond laser assisted cataract surgery with and without NSAID and correlation with postoperative inflammation and cystoid macular edema
  • Prospective intracameral moxifloxacin endothelial safety study in patients having cataract surgery comparing 500 mcg/0.1 ml in one eye and 250 mcg/0.1ml in the opposite eye.
  • Evaluation of posterior capsular changes, IOL glistening and visual outcome after implantation of VivinexTM intraocular lens (IOL) in routine clinical practice
  • Visual Outcomes of SMART SICS
  • A retrospective study of causes of poor visual outcome in cataract surgery patients (phacoemulsification)
  • Comparative study of pre-operative reference marking for Toric Intraocular lens by manual toric marker over slit-lamp and by electronic device (ASICO TORIC MARKER)
  • Comparison of Intraoperative Posterior Capsular Rent (PCR) and Zonular dialysis (ZD) in Mature cataracts in SICS and Phacoemulsification at Aravind Eye Hospital Madurai
Retina
  • Microperimetry biofeedback training in patients with irreversible bilateral vision deterioration
  • CLS1003-301, SAPPHIRE: A randomized, masked, controlled trial to study the safety and efficacy of suprachoroidal CLS-TA in conjunction with IntravitrealAflibercept in subjects with Retinal Vein Occlusion
  • ARDA (Automated Detection Algorithm) Assisted Read Study Protocol – ADRES related Study
Uvea
  • Efficacy and safety of posterior subtenon’s triamcinolone acetonide,intravitreal triamcinolone acetonide,intravitreal bevacizumab,intravitreal ozurdex for treatment of uveitic cystoid macula edema
  • First-Line Antimetabolites as Steroid-sparing Treatment (FAST)Uveitis Trial
Paediatric
  • Visual functions as determinants and VEP as predictor of response to the treatment in Amblyopia
  • Visual dysfunction in Autism Spectrum Disorders
  • Safety and efficacy of E/d Atropine 0.01% for control of progression of myopia
  • Study of accommodation in patients with Idiopathic Infantile Nystagmus (IIN)
  • AEH – Orbis Refractive Error among Children (REACH) Project
  • Assessment of distance and near stereoacuity, fusional amplitudes in patients with IXT and their change after surgery
  • Assessment of reading visual acuity in patients with nystagmus
  • Translational genomics of paediatric eye diseases
Low vision
  • Hospital anxiety and depression scale assessment of patients with low vision before and after using low vision care: A prospective study in a tertiary eye-care setting
Neuro-ophthalmology
  • Quantification of Relative Afferent Pupillary Defect (RAPD) by an automated pupillometer (RAPID) and its relationship to visual acuity, color vision, visual fields before and after treatment of patients with optic neuritis and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Cornea
  • To compare Spectral Domain Optical Coherence Tomography (SDOCT) and Pentacam to assess corneal scars
  • Impact of aberrations post Descemet?s stripping endothelial keratoplasty on visual outcome comparing methods of specimen collection in deep keratitis cases
  • Parasitic ulcer treatment trial
  • Mycotic ulcer treatment trial
  • Acanthamoeba Keratitis longitudinal study
Orbit
  • National retinoblastoma registry – ICMR
  • Translational Research to Generate Corneal/Buccal Epithelial Stem Cells with GMP Compliance for Corneal Surface and Socket Reconstruction
  • Identification of mitochondrial biomarkers in retinoblastoma
  • Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets
  • An open label, prospective clinical evaluation of safety and efficacy study of Aurostent (Silicone mono canalicular lacrimal stent manufactured by Aurolab, Madurai, India) in the treatment of canalicular injuries and anomalies
  • Establishing the genetic testing centre for childhood ocular cancer (retinoblastoma) in Aravind Medical Research Foundation